Ozempic/Wegovy May Be Causing Increase in Rate of Stomach Paralysis

Sorry, just very touchy about it. She’s tried everything and it’s been very difficult for her. People that say “just exercise more, eat less” as if that’s the ONLY answer.

These types of problems affect women far more than men. These issues started when she was an older teenager that swam approx. 6 hours a week and coached swimming. She was very active and watched what she ate and the weight still came.

The compounded semaglutide is helping in conjunction with workouts on her peloton.

Didn’t mean to come across quite so snarky but the “just watch what you eat” doesn’t always work.

 

Have her talk to her doctor about trizepitide( mounjaro). It is showing better outcomes with less side effects.
There is also another drug in trials right now called retatrutide that is blowing the other two away as far as weight loss outcomes in a shorter timeframe.

 

We’ve talked about her before. This is a last resort attempt. Nobody has been able to really figure it out.

When she was in HS we had her do the VO2Max testing and the guy that did it was dumbfounded. Said with her metabolism she was one step up from dead Again, this was from a competitive swimmer that swam 6+ hours a week.

I’ll pass along the info. Thanks

 

Retatrutide works on 3 different receptors vs 1 for ozempic is my understanding

 

Correct

https://www.nejm.org/doi/full/10.1056/NEJMoa2301972

 

Agreed. I’ve been on a “low carb” diet going on 10 years now. The only time I’ve maintained full blown ketosis was before the kids ate food. Since then too many snacks in the house to stay in ketosis but my overall carb intake has been greatly reduced. I went from 235 to 175 while in ketosis. If it were up to me the kids wouldn’t eat junk either, but my wife likes the junk too.

 

That's one hell of a way to lose weight.

 

What’s the long term effects of taking these drugs?

 

The fact is that “exercise more and eat less (or better)” does work for the very great majority of people who want to either lose or maintain a healthy weight. But way too many people want to take the easy way out by taking these “miracle” drugs.

I know a bunch of people who are not grossly overweight or diabetic but somehow have have found doctors who will prescribe these weight loss drugs to drop unwanted pounds. Again, these drugs are good for those who truly need them but if you choose to not eat healthy or exercise, unfortunately there is a good possibility it will eventually catch up to you.

 

After getting some less than optimal cholesterol and coronary calcium numbers, I finally decided to get serious about it, lost 30+ lbs over a little less than a year. Mainly by logging everything I eat, reducing the amount of junk food, and trying to keep calories in check. I’ve probably averaged 2200-2400 per day. Also adding more exercise - walking, plus cardio and modest weights at a gym.

I have been traveling on vacation for almost 3 weeks and kind of fallen off the wagon. The change of routine has thrown sand in the machine.

I would consider these drugs a last resort. There probably will be side effects for some people. Nonetheless for most people lifestyle changes just don’t work, they are too hard to maintain, and I suspect you are better off taking the drugs than being obese and diabetic.

The concerns I hear are that for some people there is a high degree of muscle mass loss as well as far loss, sometimes as much muscle as fat. Some muscle mass loss is inevitable in any rapid weight loss strategy, but doing this and not exercising may not be doing you as much good as you think.

Also heard anecdotally that these drugs tend to increasing your resting heart rate while sleeping FWIW.

 

The problem here is people are taking the meds without lifting weights.

These drugs are tools to be used with proper dietary changes and an exercise plan. They shouldn't be the only thing you are doing.

I have clients that are taking it that are dropping fat but maintaining their muscle mass because we have them lifting weights and increasing their protein intake compared to the way they were eating before hand.

Together, we are changing their lifestyle and habits not just dropping weight.

 

Make no mistake, we are just seeing the beginning of this class of drugs. There are billions to be made combatting the obesity epidemic in this country.

Pharma is already working on a pill form to lower the barrier of use. Also several of the weight loss companies have jumped into the fray by incorparating the use of these drugs into their programs. Both Noom and Weight Watchers have both started telemedicine companies to direct their customers to these meds. Jenny Craig sold out to Nutri systems. Its just a matter of time before these drugs are commonplace.




Just look at Ketamine therapy. It started as an off brand use for PTSD and depression in clinic. Now Mindbloom is offering self administered home therapy through telemedicine.
Mindbloom: ketamine therapy for anxiety and depression

 

phase 2 trials for semaglutide started back in 2008. When it was approved doesn't mean it hasn't been studied for years.

 

If you are on these drugs then you have to weight train. The weight loss is so fast that you will lose your muscle. This makes it much easier for you to rebound if you ever stop taking this medication. I will stress again that you have to increase your weight training if you are on these drugs.

 

Really key to read the label.

Many listed side effects

I always tell fam to also read the package insert


Gastrointestinal (GI) events are well-known side effects of the GLP-1 class. For semaglutide, the majority of GI side effects are mild to moderate in severity and of short duration. GLP-1’s are known to cause a delay in gastric emptying, as noted in the label of each of our GLP-1 RA medications. Symptoms of delayed gastric emptying, nausea and vomiting are listed as side effects,” the statement said.

 

2008? That is a long time

 

For drug trials. sure.

It was studied far longer than the "vaccine" and look how many have complete faith in it.

But I agree, we won't know the long term side effects until it actually has been a long time.

 

Yup, some muscle mass loss is inevitable for a large majority of people, especially if you're losing a lot of weight and regardless of done with drugs or not. Not sure if these drugs increase the loss of muscle mass, however.

 

$300/month is too expensive. I'd recommend ordering from the same place that Empower gets their supply and just reconstitute it yourself