Musk, Kennedy disagree on weight-loss drugs

Here in the US, there are myriad companies that offer compounded GLP-1 medications (generic Ozempic) for $300/ month (4 x1 weekly injections).
This is out-of-pocket.

 

Wrong yet again. Why do you continue to post your opinion as facts?
BigPharm already markets these GLP-1 drugs specifically for weight loss.
These drugs include Wegovy and Mounjaro.

 

As I said, more dogma in the fitness and nutrition space than in organized religion. Probably the primary reason that I self-excommunicated.

 

Oh, that's what the new commercials are for. My bad again. The lobbiests have already won.

 

OMG! I didn’t see this coming. Public health is jumping on this like they jumped on vaccine harms *sarcasm*

Could Ozempic and Wegovy Be Linked to Blindness? | Mass General Brigham

 

Actually Viagra was being studied for pulmonary HTN, but while the trial was on going men noticed the “side effect”.

The GLP1 class until recently had no had any studies specifically for weight loss. Lilly got theirs approved for wt loss based on a wt loss trial.
Typically each new indication needs a trial for that group of patients.

Novo-nordisk did a 4 year Cardio vascular risk reduction study to prove lowering HBA1C in cardiovascular risk patients lowered the incidence of heart attack and stoke.

 

The US subsidizes the drugs for the world.

 

No they ran clinical trials to prove it was safe and effective in non-diabetic patients to get the approval for that indication.

It has zero to do with marketing or lobbying.

 

Spend 5k to save 200k or more.

 

The biggest issue is loss of muscle mass.
There are newer ones in trials that have much less of that.

Some people also can have nausea and vomiting and constipation as well. This is in large part because it slow gastric motility and people “feel” full faster.

 

Nah that’s because we are the fattest country in the developed world. You know that.

 

For certain patients, fine. I have no issue with that. But you and I both know where this will go, right down Viagra Blvd.

 

The commercials are definitely about marketing. We're literally the only country in the world that has them, and as I hear it they represent nearly or over 50% of the total ad buy nationally.

 

I'm still convinced that the reason for the loss of muscle mass is the rapid weight loss compounded with the fact that most people don't lift weights

 

Look. If you want to learn something that might be valuable to your family when it comes to health. Read Blind Spots. There is some really good information on the medical dogma out there are Dr. Makary puts it.

I am not here to play your gotcha game. And then play let you start your circular argument so you can have your circle jerk.

You really could learn something. But sadly you might be stupid enough to ignore it because I brought it up.

 

You very well may have a point.
Increasing protein intake may help as well.

Newer drugs in trials seem to have less lean muscle loss.
Viking Pharmaceuticals has one.

They are also finding it helps lower fatty liver content which can lead to non alcoholic cirrhosis.

 

But your suggestion was they were doing that to get it used for weight loss.
While it has been used off label it’s only recently been approved for weight loss so insurers weren’t under any pressure to pay for it.

 

You clearly have no idea what you read, as you are saying things that don't make the slightest sense from a statistical standpoint. As best as I could tell, researchers ran a study testing the hypothesis that HRT results in lower weight. The study did not reject the null hypothesis due to a lack of a statistically significant difference in some weight related DV between the control and treatment groups. But you say that the drug was effective, which is not demonstrated (see previous sentence). And you back it with a bunch of stuff that makes no sense from a statistical standpoint, in which you clearly dont understand the definitions/meanings of the terms that you are using.

To help you out: a p-value is a probability that the null hypothesis would be true given the empirical data. A confidence interval is the region of a curve within which there is some percentage likelihood that the true value of a parameter is found in the region (often, in statistics, 90%, 95%, and 99% are used). I suspect that you are trying to describe one of the following things: z-score, t-statistic, or F-Statistic, but it is impossible to tell.

 

The reason for the loss of muscle mass is the lack of calorie intake due to appetite suppression. Muscle demands lots of energy to maintain its mass. Without it your body sacrifices muscle tissue to protect vital organs and systems. While taking GLP-1's your intake should focus on protein to provide amino acids to help maintain your muscle. Weightlifting is just a stimulus to muscle growth. lifting breaks down tissue while nutrition builds it back up. If you get the nutrition right, your body will use stored fat as a supplemental energy source while sparing most muscle mass. When in a heavy caloric deficit, you will always lose both muscle and fat. The trick is setting up a moderate deficit using the meds to make it doable so the person will stay compliant to the program while losing as little muscle as possible.

Working with my clients that take GLP-1's, this is my approach. I have said since these meds have come out that a combination of the drug along with nutrition education should be prescribed to optimize the results.

Personally you shouldn't get a Rx without a plan from a nutritionist/RD. At the very least you should be working with a UF educated trainer with an exercise science degree and over 25 years of experience.