Coronavirus in the United States - news and thoughts

In just our 3rd year of studying the novel coronavirus that led to the COVID-19 pandemic, we have made, and published, yet another small step forward towards understanding the origin of the virus. Or, more correctly, knocking down one more unsubstatiated argument that this HAD to be created in a Chinese lab. The current paper, defeats the argument that SARS-CoV-2 was manipulated in the lab because it possessed the S1/S2 furin cleavage site, which was alleged to not appear in nature on coronaviruses. Oops, here come those nasty actual scientists again, unlike frauds and charlatans like Lapado and criminals like him. Actual scientists, publishing their data in an attempt to further our understanding of this virus.

A Novel Bat Coronavirus with a Polybasic Furin-like Cleavage Site - ScienceDirect

 

Actually for most there are little or no long term issues with semaglutide.
Other than weight loss, loss of fat(apoptosis) lowering LDL, lowering risk of heart attack, lowering A1C thus lowering inflammation and likely lowering risk of stroke.
For people who have tried diet and exercise without success the GLP1 class of drugs are very effective and often not needed for more than a few months.

Semaglutide has been studied in diabetics for like 5 years in at least one long term safety and outcome study.
That’s doesn’t include the phase 1,2,3 trials which allowed the FDA to approve the drug in 2017.

 

I’m not making a judgment against it. Just putting it up as a comparison.

From what I read the issues are

- most people lose a lot of muscle as well as fat. The percent of weight loss that is muscle is typically somewhere around 30%.

- there is some evidence that it increases your resting and sleeping heart rate, to the extent that is even an issue.

- You are probably looking at using it for the rest of your life, because when you quit over time you typically gain the weight back. I’m not sure we have much info on what the long term effects are.

Having said that, for those that are significantly obese and have failed multiple attempts at weight loss, the drugs are probably a better alternative than continuing to be obese and develop diabetes and cardiovascular disease.

 

Just spit my wine out…

Thanks for the laugh. That was funny!

Pfizer appreciates you.

 

You smoking tonight?

 

If so you might be part of the 1% still getting this shot lol. On Saturday no less. LOL!

 

The drug doesn’t cause muscle wasting it does cause fat cells to be broken down and used for energy.

I’m sure some gain the weight back, not a shock when they go back to that 5Kcal diet again.

5 year study showed lots of info. Far more info than the covid vaccine boosters on possible long term issues considering it’s barely been 3 years since the trials started.

 

Actually last I saw it was about 15-20% getting the altered booster.

 

I was being hyperbolic there…

But no way 15-20% getting it imo. 10% I could see.

 

The drug doesn’t cause muscle wasting. It’s the dramatic reduction in calories, including proteins, that causes muscle wasting. That could be mitigated with exercise and deliberate protein intake, but most people aren’t going to feel like doing that.

This could be a side effect of any rapid weight loss regimen.

Again, the benefits outweigh the risks for the morbidly obese.

As to vaccines and long term side effects, again, there have never been recorded long term unknown side effects to any vaccine. So 3 years out it is highly unlikely that you will see unexpected new side effects. But sure anything is possible. A meteor may smash the planet tomorrow.

 

I appreciate Phizer. There is so much ignorance out there and while I can't isolate myself from these people, I can take steps to minimize the potential for them to adversely impact my health.

By the way, no one likes a spitter.

 

Causing your body to unnecessarily work…with a drug that does not work…is not going to do you any good. But you go for it. Pfizer appreciates you.

Now if you are getting in some exercise and focusing on your diet…you will be doing something.

 

The main reason people are anti-vax is because they know now, as never before, that they can be lethal.

 

Interesting evolution of Pfizer's vaccine. The paper discusses BNT162b4 (current vaccine is BNT162b2).

This targets T-cells, known to play a key role in the human immune response to corona viruses in preventing severe disease. This version of the vaccine will "encode" variant conserved proteins not on the spike. Meaning, most/all of the amino acid pair changes that effect the spike and the binding of the virus, will not allow the virus to easily evade this version of the vaccine.

However, again, like all other vaccines, it does not target preventing infection, it targets preventing disease/severe disease. Pfizer is evaluating this as a stand alone shot, or in combination with the bi-valent BTN162b2 - which boosts neutralizing antibodies much more effectively, even though that benefit is transitory.

https://www.cell.com/cell/fulltext/S0092-8674(23)00403-8

 

Have you given any thought to just not posting the same stupid, wildly incorrect shit again and again?

 

You will get there one day. Certainly taking longer for a small percentage like you…

 

You're in the overwhelming minority of people on this topic. 83% of adults in Florida have taken the vaccine. You're part of the 17% - not me.

And you won't ever get there. You simply can't wrap your brain around it.

 

So if I read this correctly, they have a new vaccine version that is better at T cells and may bring better longer term immunity against severe disease?

I’m not sure I totally agree about goal/infection. I will agree that the primary goal is to reduce severe disease. But in some cases, primarily in longer incubating and less evolving variants, eliminating spread via infection is a way to eliminate severe disease. Of course that doesn’t work with viruses like Covid and the flu.

 

That is never a goal of a vaccine, that is simply benefit of slow incubation. There is almost no vaccine that we can name that prevents infection, including small pox. Small pox is just so slow to incubate that your immune system, if properly perpared through vaccine or previous infection, can react and overwhelm the virus.

The same is true of all COVID vaccines.