Covid-19: Treatments, Cures, and Vaccines

It can only be used in hospitals, but the problem is that almost every state is saying that they are running out as soon as their latest allocation from the federal government arrives. Back in late May and June, most than 20% of cases were being treated with it. I know for a fact it is standard procedure here in Central North Carolina for people severe enough to be admitted to the hospital. I know that from my uncle who is down in S Carolina that it is the standard treatment as well......but, the hospitals are critically low to out almost all of the time since the post Memorial Day surge in stupid behavior leading to hospitalizations.

 

Operation Warped Reality has increased its investment into the Modern Vaccine candidate (again). A large (30,000 people) Phase 3 clinical trial gets under way tomorrow (Tuesday 7/27). Between this one and the Pfizer/BioTech vaccine candidates, BARDA has committed ~ $3 Billion. These two vaccine candidates attempt to attack all (Moderna) or some (Pfizer) of the spiked protein, we better hope that this is the correct approach or the government just flushed $3B.

Moderna Announces Expansion of BARDA Agreement to Support Larger Phase 3 Program for Vaccine (mRNA-1273) Against COVID-19

 

Hydroxychloroquine & Z- Pac for me! It worked in December & January for me!
Standing orders to my dr.
hbgator.

 

Just think though , if you'd gone ahead and injected the bleach... you wouldn't have needed treatment for both months.

 

Where were you living that the doctors thought that they were treating Covid-19 and how did they come up with this combination?

 

Uh oh, black and female...how's a good lib to slander?
Alice Down the Rabbit Hole

 

Treatment with Hydroxychloroquine Cut Death Rate Significantly in COVID-19 Patients, Henry Ford Health System Study Shows

In a large-scale retrospective analysis of 2,541 patients hospitalized between March 10 and May 2, 2020 across the system’s six hospitals, the study found 13% of those treated with hydroxychloroquine alone died compared to 26.4% not treated with hydroxychloroquine. None of the patients had documented serious heart abnormalities; however, patients were monitored for a heart condition routinely pointed to as a reason to avoid the drug as a treatment for COVID-19.

FYI

 

Renal insufficiency prevents its use however.

 

From the study:

All of the randomized controlled trials have shown no medical benefit and negative side effects.

 

And the argument has been all along that its use needs to be started earlier in the course of disease. Not waiting until people are too sick for it to help.

Think of telling the guy that just had the MI stop eating triple cheeseburgers every day. It wont help his heart attack because its too late.

 

I looked at the FDA website for active clinical trials. If I have read the information correctly (and there is definitely some question about my level of understanding, but....) there are at least 3 randomized, blind trials targeting patients earlier in the disease cycle and or more mild cases of Covid-19 for treatment with Hydroxychloroquine.

From what my pod-cast nerds have said, it is likely not a question of if there is a benefit, it is how much and at one point in the infection. Very similar to what you said above. So, it does not seem like people have totally abandoned studeis/research into this drug.

 

Good news out of Johnson & Johnson pre clinical study. J&J has already moved to Phase1/2 trials with humans testing for safety and has accelerated its timeline to Phase 3 large scale trial to September. This vaccine candidate is different from the Moderna and Pfizer candidate. The vaccine candidate is based on the same technology recently used to develop its successful Ebola vaccine regimens (combined two vaccine candidates combined) which was granted authorization for use by the European Commission on July 1, 2020.

Single Dose of Johnson & Johnson COVID-19 Vaccine Candidate Demonstrates Robust Protection in Pre-clinical Studies

 

Fascinating summary of a Nature article describing work by European researchers. In short, it is possible (not proven, but possible) that previous encounters with other Coronaviruses may help modulate the human response to SARS-CoV-2. It does not appear to keep you from getting infected, but may greatly reduce the severity of the infection.

Immune T Cells May Offer Lasting Protection Against COVID-19

 

These are pretty important drug candidates. I think if there was an oral treatment that could reduce the likelihood of hospitalization and serious longer term effects, that would go a long, long way towards getting us back closer to normal.

Merck aims to start 'large pivotal' studies on coronavirus treatment in September

 

COVID-19 Breakthrough: Scientists Identify Possible “Achilles’ Heel” of SARS-CoV-2 Virus

 

Another new treatment that seem to show promise.
Relief, NeuroRx say emergency treatment with RLF-100 helps critically ill Covid patients

 

Eli Lilly setting up Mobile Research labs to perform/collect data on 2400 long term care facility patients treated with their antibody LY-CoV555 in the hopes that the antibody treatments will prevent these patients from developing infection if exposed to the SARS-CoV-2 virus. It is a very meaningful Phase 3 trial in that sense, as the entire trial is targeting some of the most vulnerable in our society.

Lilly starts phase 3 test of COVID-19 antibody in nursing homes

 

Any thoughts on potential side effects of this approach?

 

After other countries have been using this technology for months now, the FDA is finally off its politically influenced arses and getting serious about wide scale, rapid testing that is "good enough". This is the stuff that could have been done months ago and deployed in time for schools to have a prayer of opening.

By the way, the Quidell solution, as well as another by a company not listed below (BD Scientific) have been in used in Asian countries since May.

NIH picks seven COVID-19 diagnostic tests in 'Shark Tank' competition, unlocking $248.7M in scale-up funding

 

Regeneron, already testing humans with its anti-body cocktail in infected patients, is now starting a 2000 person human Phase 3 trial to see if the cocktail will prevent those exposed to infection to keep from becoming infected themselves.

Regeneron kicks off prevention trial for COVID-19 antibody cocktail