Coronavirus in the United States - news and thoughts

Agreed, that's a big issue and this has been discussed among the medical community already.

Experts worry next studies of Gilead Covid-19 drug may add uncertainty

 

Until they define their "primary endpoint" that it met the NIAD study is meaningless too. they offer vague terms with no meaningful definitions or basis for comparison. Science should not be allowed to publish like that.

Is their primary endpoint to increase lifespan by 1 day or to increase survival rate by 1% or 50% or ??? Inquiring minds want to know...I suspect that it will be a very low bar set by a political decision and not a scientific one.

Did you notice Birx is now moving the target on the antibody reliability down to 90% now..sounds good until you realize that if we get 20 positive tests 10 of them could be wrong. Kind of destroys that whole total % infected argument when the tests are off by 50%, although they are 90% accurate. the average American can't understand that math or chooses not to.

 

I understand the skepticism but do you really think Gilead would do a study and be positive if it only improved lifespan by 1 day or survival rate by 1%?

This was from 2 weeks ago but it is pertinent to the subject.

Gilead data suggests coronavirus patients are responding to treatment

Lets wait but it's ok to be positive and not negative.

 

One can be optimistic while also remaining realistic about facts of the study. They aren't mutually exclusive. People like @dingyibvs (i.e. medical professionals that are actually on the front lines) have every right to scrutinize studies.

 

Who's saying he can't scrutinize studies? I'm saying this is a positive. Period. And the NIAID trial Dingy didn't know about. This is good stuff.

 

I understand you are saying this is a positive. I'll deflect judgement of what's positive and what's potentially not positive (no sense in using the word negative) to the professionals though.

 

As am I. Look at the University of Chicago study. By Doctors.

 

Ok cool. Either way it doesn't really matter how you or I view the study as it will all shake out in the end.

 

I'd like to look at it, but we don't have the data yet. We're all eager for good news, but we can't conflate what we want with what the reality shows. We also need to be prepared to change our thinking with every new data that comes along.

My suspicion is that all of these meds need to be administered early to show a large benefit. Most trials currently focus on people admitted to the hospital, and we may be wasting our time trying to find tiny benefits among this population.

 

Fauci: Gilead Trial Shows Significant Positive Effect On Virus

 

This is exactly why I avoid the news these days.
Even the uk folks who tweeted about this said the number of cases were small and that it’s still very rare for children to have serious complication from Covid, Stanford has exactly one case, and yet this is now a worldwide story.
It’s no wonder mental health is deteriorating.

 

Trump says he doesn't want another stimulus check, would rather cut social security tax. Congrats, not like it was in doubt but you just lost the election if this remains true.

'Pathetic': Trump Says No to Additional Covid-19 Stimulus Checks, Backs Cutting Tax That Funds Social Security Instead

People need money to pay their bills, they don't need to be waiting around for a tax break while cutting SS...

 

these things seem to be intentionally vague to get hope, and stock price, up. I am more of an under-promise, over deliver type. While I am hopeful that something is going to break through with respect to treatment and/or vaccine, the vague generalities and lack of specificity in the releases doesn't give me much hope that this one is it. this isn't a time for cheerleading, it is time for science and reality, jmo.

 

I find it to just be another interesting effect of the virus, like clotting causing strokes. not trying to induce mass hysteria but much like strokes, not many were thinking about the Kawasaki syndrome being related to covid until someone told them to look. the more we understand how the virus effects people hopefully the more we can zero in on treatments

 

Science and reality was the University of Chicago Study. You can downplay it as you've done. I won't. Didn't realize I am head Cheerleader. But would rather be considered that right now than Negative Nelly. And Gilead stock would be destroyed if they released this to raise their stock price. First off, that would be an SEC violation. Second, there is the NIAID Study which is independent of Gilead's own study plus you have the University of Chicago Study. Doubt all those are in bed together to make the stock price go up.

 

Gilead says it had no control, or placebo, group to measure against. Fauci says something 180 degree opposite. Which one is it? Or were these 2 different studies?

Gilead Virus-Drug Trial Signals Hope, and Fauci Sees ‘Good News’

Fauci called the study the “first truly high-powered randomized placebo-controlled trial” of remdesivir.

Gilead says early results of coronavirus drug trial show improvement with shorter remdesivir treatment

The clinical trial involved 397 patients with severe cases of Covid-19. The severe study is “single-arm,” meaning it did not evaluate the antiviral drug against a control group of patients who didn’t receive the drug.

 

Multiple studies.

 

Di

do you know that the Chicago study that claimed to be for the severely ill specifically excluded anybody on ventilation, ie the people with real O2 problems? The results of that study are encouraging but the pre-selection bias may be impacting the results. I really hope this works

 

From an economic standpoint it doesn't seem to make much sense. People who have safe jobs and safe businesses will benefit the most. If you are cutting employees as a business owner, you get relatively less benefit. If you are an employee with a safe job, you relatively benefit more than if you are somebody not working. Honestly, those of us with safe jobs don't need the stimulus. My personal expenses are down and not due to concerns about my income.

 

Yes, but they were classified as severely ill and IF Remdesivir can keep people from going on a ventilator that would be a home run. Keep being pessimistic, it seems to be your M.O.